Clostridioides difficile, formerly known as Clostridium difficile, is a bacterium that can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon. It is a leading cause of healthcare-associated infections and can be particularly problematic in hospitals and healthcare facilities where antibiotic use is common. Research in this area focuses on understanding how C. difficile spreads, how it causes disease, and developing new treatments and prevention strategies to combat infections. This research is important for improving patient outcomes and reducing the burden of C. difficile infections on healthcare systems.